Younger Lab
About the Lab
A critical barrier in translational sciences is the lack of practical laboratory technologies with the capacity to inform evidence-based clinical treatments in a timely manner. For clinical indications with multiple therapeutic options that exhibit varied efficacy across individuals in the impacted patient population, the process of identifying the optimal therapeutic approach for any given individual can be a major bottleneck. The Younger laboratory is leveraging expertise in the generation of patient-derived cellular models and high-throughput cell-based screening to develop tools and technologies that will enable the rapid and accurate prediction of drug efficacy at single-patient resolution.
Leader
Dr. Scott Younger is the Director of Disease Gene Engineering within the Genomic Medicine Center at Children's Mercy. Since joining Children's Mercy his laboratory has pioneered methods for the rapid, robust and scalable production of patient-derived cellular models. The laboratory is currently focused on the development of platform-based approaches for functional precision medicine with an emphasis on reduction to practice and clinical implementation.
Dr. Younger came to Children's Mercy from the Broad Institute of MIT and Harvard where his group worked on the development of new methodologies to expand the utility of CRISPR-based genetic screens. Prior to working at the Broad Institute, he completed his postdoctoral studies at Harvard University as an American Cancer Society Fellow. He holds a PhD in cell and molecular biology from UT Southwestern Medical Center. He also received an MS in biotechnology from the University of Texas at San Antonio and a BSI in bioinformatics from Baylor University.
- Research Areas
- Labs and Research Teams
- Baby Health and Behavior Lab
- Baby Lab
- Bactrim Lung Failure Team
- Behavioral Pain Innovations Lab
- Center for Children’s Healthy Lifestyles & Nutrition
- Community Engaged Research Team
- Developmental and Behavioral Health Research Group
- Fridley Lab
- Laboratory of Immunogenomics
- Milkovich Lab
- Nadler Lab
- Orthopedic Surgery Research Team
- Pediatric Brain Cancer Research Team/Yadav Lab
- Ramsey Lab
- Varberg Lab
- Younger Lab
Director, Disease Gene Engineering; Associate Professor of Pediatrics, University of Missouri-Kansas City School of Medicine; Research Assistant Professor of Pediatrics, University of Kansas School of Medicine