About the Study

Cystic Fibrosis: A study in pediatrics for treatment of respiratory infections

This study is beingdone for children and young adults: • Ages 3-18 • Diagnosed with Cystic Fibrosis Cystic Fibrosis (CF) causes periods of new or increased cough and other respiratory symptoms called pulmonary exacerbations. Exacerbations are often treated with antibiotics and increased airway clearance. In milder pulmonary exacerbations (respiratory illnesses) that are managed at home, we don't know if antibiotics are always necessary. In this study, we are going to compare two ways of treating mild respiratory illnesses in children with CF: immediate antibiotics (increase airway clearance and start oral antibiotics right away) or tailored therapy (increase airway clearance right away but only start oral antibiotics if symptoms worsen or do not improve). We are looking at how safe each option is and how well each one works. To do this, we will randomize you (like flipping a coin) to one of these two approaches if or when you have a mild respiratory illness over the next 12 months.

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Full Study Name: STOP-Peds